北京優(yōu)尼康生物科技有限公司主要經(jīng)營進口、國產(chǎn)生物科研儀器、試劑及耗材，提供技術(shù)服務的生物公司之一。現(xiàn)經(jīng)營的品牌及相關產(chǎn)品如下：

德國Griner培養(yǎng)板、培養(yǎng)皿、離心管、凍存管、培養(yǎng)瓶、接種環(huán)、接種針等；

美國Wheaton 勻漿器、組織研磨器、雙側(cè)壁細胞培養(yǎng)瓶、懸浮細胞培養(yǎng)瓶、細胞專用攪拌器、安培瓶等玻璃儀器。

美國kimble 藍蓋瓶、勻漿器、離心管，巴氏吸管等玻璃儀器；

加拿大Labplas 的無菌采樣袋、均值袋；

美國Nalgene 過濾裝置、塑料廣口瓶、放水桶、低溫冰盒、低溫標簽、記號筆、離心管、凍存管、便攜液氮罐、無菌培養(yǎng)基瓶、手動真空泵等

美國ABI PCR板、PCR管、PCR蓋子、八連拍管、膜等

德國Brand 移液器，電動移液器，瓶口分配等

德國艾本德eppendorf 移液器、分配器等

法國Hyphen Biomed 的出血、凝血類試劑 ；

美國BioProducts MD 的PEDF(人眼色素上皮衍生因子)；

德國IBL international 新蝶呤試劑盒、兒茶酚胺試劑盒；

美國TYLER 的篩分儀；

BD公司的基質(zhì)膠,細胞篩網(wǎng)等;

法國Interscience 均質(zhì)器、重量稀釋器、自動螺旋接種儀、均值袋、均值夾、開袋器、架子等

德國Wiggens 攪拌器、培養(yǎng)箱、振蕩器、蒸發(fā)器（氮吹儀）菌落計數(shù)器本生燈、均質(zhì)器等

德國Chemvck 防腐隔膜泵、無油泵、真空泵、蠕動泵等

瑞士Keller 小型快速玻璃珠滅菌器、玻璃珠等

美國Millpore 細胞電阻儀、超濾管、膜、針頭濾器等

美國 BioSpec研磨珠均質(zhì)器、手持勻漿機等

自產(chǎn)鎳洛合金接種環(huán)、接種針、核酸染料等

SP600125 is a selective, reversible and ATP-competitive inhibitor of Jun N-terminal kinase (JNK) with IC50 values of 40, 40 and 90 nM for JNK1, 2 and 3, respectively [1].

SP600125 was screened out from a time-resolved f luorescence assay using the GST-c-Jun and recombinant human JNK2. In this assay, SP600125 showed a Ki value of 190 nM. SP600125 was also found to inhibit JNK1, 2 and 3 isoforms in the selectivity tests. The selectivity of SP600125 for JNK is 300-fold greater than that for ERK1 and p38-2. In Jurkat T cells, SP600125 suppressed the phosphorylation of c-Jun with IC50 of 5-10 μM. SP600125 also inhibited the expression of IL-2 and IFN-γ in cells stimulated with PMA and phytohemagglutinin, since JNK had been reported to regulate the transcription of IL-2. Besides that, SP600125 exerted differential inhibition of cytokines in CD4+ cells as well as inflammatory genes in monocytes. Moreover, SP600125 administration significantly inhibited TNF-α expression induced by LPS in a mouse model, suggesting that it had efficacy in endotoxin-induced inf lammation in vivo [1].

References:
[1] Bennett B L, Sasaki D T, Murray B W, et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proceedings of the National Academy of Sciences, 2001, 98(24): 13681-13686.